[an error occurred while processing this directive]
International Journal of Infectious Diseases: Volume 5, Number 1
Effect of Surfactant and Specific Antibody on Bacterial Proliferation and Lung Function in Experimental Pneumococcal Pneumonia
Xiaozhuang Gan, MD; Connie Jarstrand, MD, PhD; Egbert Herting, MD, PhD; Per Berggren, MD; and Bengt Robertson, MD, PhD

Int J Infect Dis. 2001. 5(1); 9-18.

Objective: To investigate the effect of surfactant and specific antibody on bacterial proliferation in experimental pneumococcal pneumonia.

Methods: Near-term newborn rabbits received a standard dose (107) of type 3 pneumococci via the airways. Control animals were sacrificed 1 minute later. Other animals were ventilated for 5 hours and treated via the tracheal cannula with surfactant (Curosurf 200 mg/kg), a mixture of surfactant and a polyclonal antipneumococcal antibody, the antibody without surfactant, or saline.

Results: There was a significant bacterial proliferation in lung tissue in all animals ventilated for 5 hours. Bacterial growth, expressed as log10 colony forming units (CFU) per gram of lung tissue was less prominent in animals treated with a mixture of surfactant and specific antibody than in animals treated with antibody alone (median, 7.51, range, 6.80-7.70 vs. median, 7.92, range, 7.07-8.50; P < 0.05). Dynamic lung-thorax compliance was improved with surfactant or surfactant plus antibody in comparison with saline or antibody alone.

Conclusion: The data suggest that the suppressive effect of the antibody on bacterial proliferation becomes evident only when surfactant is administered together with the antibody.

Key Words: pneumonia, polyclonal antibody, pulmonary surfactants, rabbits, respiratory function, Streptococcus pneumoniae

Back to Table of Contents



The International Journal of Infectious Diseases is owned by
the International Society for Infectious Diseases.
The Journal is published quarterly for the ISID by B.C. Decker Inc.