Epidemiology and Management of Diarrheal Disease in HIV-Infected Patients
Elly T. Katabira, MD
Int J Infect Dis 1999; 3: 164-167.
Diarrhea is the most common gastrointestinal symptom in human
immunodeficiency virus (HIV) infection. It affects up to 90% of patients, becoming
more frequent and severe as the immune system deteriorates. It often is associated
with significant morbidity and mortality particularly in the developing countries.
Gastrointestinal infections, some of which are attributable to inadequate sanitation
and poor hygiene are the predominant cause of diarrhea, although multiple
medications, including traditional herbs, also may be causes. The basic principles of
management include detection of treatable causes, relief of symptoms, prevention of
malnutrition, and psychosocial support. In up to 60% of cases, no cause can be
identified, partly because of inadequate investigative facilities. Symptomatic
treatment is the mainstay of management particularly when no cause can be
identified. Unfortunately this can be extremely difficult when the patient is severely
immune-suppressed. There is poor response to motility control drugs, such as
loperamide, and others, such as octreotide, are too expensive. Fluid replacement
should be started early to prevent excessive dehydration. This should be combined
with nutritional support to prevent malnutrition. Psychosocial support, including
counselling, for both the patient and the caring relatives, is required to alleviate
anxiety, particularly when the diarrhea becomes intractable.
KEYWORDS: counselling, diarrhea, education, HIV, nutrition
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