[an error occurred while processing this directive]
International Journal of Infectious Diseases: Volume 3, Number 1
Prevention and Treatment of Disseminated Mycobacterium avium Complex Infection in Human Immunodeficiency Virus- Infected Individuals
Stephen D. Shafran, MD

Int J Infect Dis 1998; 3:39-47

Disseminated Mycobacterium avium complex (DMAC) infection is a common complication of advanced HIV disease, and is an independent predictor of mortality. The clinical features of DMAC infection are fever, weight loss, abdominal pain, anemia, elevated serum alkaline phosphatase, and elevated serum lactate dehydrogenase. The diagnosis is made by blood cultures; clinical diagnosis is unreliable. Chemoprophylaxis of DMAC infection with azithromycin is recommended when the CD4 lymphocyte count is below 50 cells/mm3. Established DMAC infection is treated with clarithromycin plus ethambutol, unless the isolate is macrolide-resistant, in which case the optimal therapy is uncertain. Highly active antiretroviral therapy is important in both prevention and treatment of DMAC infection.

KEYWORDS: HIV, Mycobacterium avium, prevention, treatment


Back to Table of Contents



The International Journal of Infectious Diseases is owned by
the International Society for Infectious Diseases.
The Journal is published quarterly for the ISID by B.C. Decker Inc.