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International Journal of Infectious Diseases: Volume 2, Number 4
Expansion of Epidemic Dengue Viral Infections to Pakistan
Rose Elaine Paul, MB, BS; Amina Yousuf Patel, MB, BS; Shaper Mirza, MSc; Susan P. Fisher-Hoch, MD; and Stephen P. Luby, MD

Int J Infect Dis 1998; 2(4):197-201.

Objectives: Antibodies to dengue viruses have occasionally been reported in individuals in Pakistan, but the frequency of occurrence of dengue infection in Pakistan is unclear. The first confirmed dengue hemorrhagic fever outbreak in Pakistan occurred in 1994. In October 1995, the authors investigated an outbreak of a febrile illness among employees of a construction contractor at a power generation plant in Baluchistan, Pakistan, to determine the cause of illness and recommend appropriate preventive measures. Methods: The work site and living arrangements were inspected, a questionnaire was administered, and serum samples were collected from all consenting contractor employees and their families if they lived at the camp. Sera were analyzed for IgM against dengue virus, using an enzyme-linked immunosorbent assay. Results: Interviews were conducted with 76 persons (mean age, 42 y); 95% were men. Forty-two persons (55%) reported having experienced fever, headache, or myalgia in the preceding 6 weeks. Fifty-seven subjects (75%) had IgM antibodies against at least one dengue serotype; 45 subjects (59%) had IgM antibodies against dengue serotype 2. Conclusion: This was an outbreak of dengue fever due to multiple serotypes of dengue virus. This confirms that epidemic dengue infection was present in southern Pakistan for 2 consecutive years.

KEYWORDS: dengue, enzyme immunoassay, epidemiology, fever, Pakistan, travel

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