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International Journal of Infectious Diseases: Volume 1, Number 4
Infections in Renal Allograft Recipients: A Review of the Philippine Experience
Myrna T. Mendoza, MD; Rosemarie R. Liquete, MD; Enrique T. Ona, MD; and Filoteo A. Alano, MD

Int J Infect Dis 1997; 1(4):222-225.

Objective: To determine frequency and types of infections developed by renal allograft recipients following transplantation and to relate these to their immunosuppressive therapy.

Design: Descriptive, prospective study.

Methods: At the National Kidney Institute (NKI), 513 kidney graft recipients were followed for 1 year for hospital admissions due to infectious disease. All patients were free of active infection before transplantation. Criteria for the diagnosis of infection after transplantation, including fever work-up, were provided in transplant protocols. Patients were given double or triple immunosuppressive regimens.

Results: Infection was highest during the first 3 months following transplantation. Bacterial and viral infections were noted early, whereas fungal infections and tuberculosis occurred later in the first year following transplantation. Pneumonia and urinary tract infections were the most common bacterial infections observed. Amoebiasis and malaria were observed more in patients on cyclosporine and triple regimens. Nocardiosis occurred more frequently among patients on azathioprine.

Conclusion: More tropical infectious diseases were observed. Early reduction of prednisone in the triple regimen resulted in more rejection episodes but less infection episodes. Rejection therapy influenced the outcome of post-transplant infections.

Key Words: Philippines, transplant infections

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