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| Of Flies and Men: The Role of Toll-like Receptors
in Innate Immunity |
Shizuo AKIRA, Japan
Shizuo Akira is now a professor at the Research Institute for Microbial
Diseases at Osaka University, Japan. He received his M.D. in 1977
and Ph.D. in 1984 from Osaka University. After postdoctoral work in
the Department of Immunology, University of California at Berkeley,
he studied IL-6 gene regulation and signaling at the Institute for
Molecular and Cellular Biology, Osaka University, and cloned transcription
factors NF-IL6 (also known as C/EBP beta) and STAT3. His current research
interests are molecular mechanisms of host defense and innate immunity,
which he studies primarily by generating knockout mice. |
| Community-Based Therapy for AIDS and Drug-Resistant
Tuberculosis in Resource-Poor Settings |
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Paul FARMER, USA
Paul Farmer, M.D., Ph.D., is the Maude and Lillian Presley Professor
of Medical Anthropology at Harvard Medical School and Medical Director
of the Clinique Bon Sauveur, a charity hospital in rural Haiti.
An infectious disease physician as well as anthropologist, Dr. Farmer
has worked in communicable-disease control in the Americas for over
a decade. Along with his colleagues in the Program in Infectious
Disease and Social Change in the Department of Social Medicine at
Harvard Medical School, Dr. Farmer has pioneered novel, community-based
treatment strategies for tuberculosisand also sexually transmitted
infections (including HIV) and drug-resistant typhoidin resource-poor
settings. Dr. Farmer is Vice Chief of Brigham and Womens Hospitals
Division of Social Medicine and Health Inequalities.
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| Genetic Susceptibility to Infectious Diseases:
Genomic Approaches |
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Adrian HILL, UK
Professor Adrian V. S. Hill is a Wellcome Trust Principal Research
Fellow at the Institute of Molecular Medicine and Wellcome Trust
Centre for Human Genetics at the University of Oxford. He qualified
for Oxford Clinical School in 1982 and undertook a DPhil in human
population genetics at the MRC Molecular Haematology Unit. Following
clinical training, he returned to Oxford in 1988 to the Institute
of Molecular Medicine. With collaborators in Africa and Asia he
has made contributions to the genetics of susceptibility to several
infectious diseases, especially malaria and tuberculosis, and to
vaccine design and development. His group has recently been undertaking
clinical trials of new T cell-inducing malaria vaccines. He is a
Fellow of the Royal College of Physicians and of the UK Academy
of Medical Sciences.
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| Reverse Vaccinology: Using Genome Information
to Develop New Vaccines |
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Rino RAPPUOLI, Italy
Rino Rappuoli is responsible for Chiron Vaccines Research. After
earning his PhD in Biological Sciences from the University of Siena,
he studied at Washington University of St. Louis, Rockefeller University
and Harvard Medical School. He is recipient of the Paul Ehrlich
Prize and other prestigious awards and has authored or co-authored
257 original papers, 42 reviews, 31 chapters, and 97 congress proceedings
and eight edited volumes. His field of expertise is vaccines, bacterial
pathogenesis, and infectious diseases. Dr. Rappuoli is member of
several international societies and committees, including the European
Molecular Biology Organization; R&D working group of the European
Vaccines Manufacturers; Scientific Committee of the Paul Ehrlich
Foundation; and External Advisory Group for "Control of Infectious
Diseases" of the European Union. He is co-chairman of the R/D
Task Force of the Global Alliance for Vaccines and Immunization
(GAVI).
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| Cholera in Latin America: The Paradoxical Benefits
of the Last Pandemic |
Jaime SEPULVEDA , Mexico
Jaime Sepúlveda is in his second term as the Director General
of the National Institute of Public Health in Mexico. His priorities
have included two national surveys, the National Health Survey 2000,
and the National Survey on Nutrition II, as well as the seroepidemiology
of infectious diseases, effective strategies for the control of chronic
diseases, and epidemiological surveillance. Involved in Mexican health
care at the national level for nearly 20 years, he has also been active
in health data collection, analysis, and educational campaigns. Dr.
Sepúlveda is a founder of the National AIDS Council (CONASIDA),
and the National Vaccination Council (CONAVA), which brought about
the eradication of polio in México. He has played important
roles internationally in the vaccine and prevention initiatives of
such organizations as UNAIDS, WHO, and the CDC. |
| A Hidden Epidemic: The HTLV-I Story in Latin
America |
Eduardo GOTUZZO , Peru
Eduardo Gotuzzo is the Principal Professor of Medicine, Infectious
Diseases, and Tropical Medicine at Universidad Peruana Cayetano Heredia
in Lima, Peru, where he also directs the the first ID residency program
in that country. He also serves as director of both the Alexander
von Humboldt Institute of Tropical Medicine and the Gorgas Course
in Clinical Tropical Medicine.
A past president of ISID, Dr. Gotuzzo is also former president of
the Peruvian Society for Internal Medicine and the PanAmerican Infectious
Diseases Association.
With more than 250 publications to his credit, Dr. Gotuzzo's longtime
research interests -- enteric diseases, TB, HIV, and emerging diseases
-- have broadened to include analyzing recurrent clinical patterns
among one of the largest cohorts of HTLV-I patients.
Dr. Gotuzzo is active on the editorial boards of such journals as
Infectious Diseases for Clinical Practice and Journal of Travel Medicine.
He is an honorary member of the ASTMH, an associate member of the
National Academy of Medicine, and a member of the Institute of Medicine's
Forum on Emerging Infections. |
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